Association between diabetes and blood homocysteine levels

Association between diabetes and blood homocysteine levels

Diabetes, gestational diabetes, insulin resistance and their complications

How dangerous is type 2 diabetes?

While heart attacks have obvious symptoms, many people do not take type 2 diabetes seriously, even though both diseases have the same chance of survival. The latter is not called the “silent killer” for nothing.
Near-normal blood glucose levels can prevent or delay the development of diabetes complications and slow their worsening.

What complications can I expect if my diabetes is not managed properly?

Risk of diabetic kidney damage (diabetic nephropathy) 16% 1

In patients with diabetic kidney disease, baseline blood homocysteine levels are significantly elevated and correlate with disease severity. High levels of homocysteine are a risk factor and an early predictor of the development of diabetic kidney damage in type 2 diabetic patients.2

Risk of nerve damage affecting the extremities (diabetic neuropathy) 18-35%

Elevated homocysteine is associated with the development of diabetic neurodegenerative retinopathy and macular degeneration, so too much and excess homocysteine is detrimental to the retina (diabetic retinopathy) and also promotes fundus calcification (macular degeneration). Supplementation with vitamin B9 (folate), vitamin B12 and vitamin B6 can reduce the risk of macular degeneration by 34% and macular degeneration, which significantly affects vision, by 41%.3, 4

Risk of disease of the optic nerve of the eye (diabetic retinopathy) 12%

Long-term high or fluctuating blood sugar levels damage the walls of tiny blood vessels (capillaries). The best and most effective way to prevent and treat the ocular complications of diabetes is to maintain optimal control of blood glucose levels, blood pressure and blood lipids over time.5

But what is homocysteine?

Homocysteine is an amino acid that is essential for normal cell function, but high homocysteine levels have undesirable effects. These include the symptoms listed below, but in addition to these, over 100 diseases or conditions, mainly cardiovascular, have been identified that are associated with elevated blood plasma homocysteine levels.6 Read more about homocysteine HERE.

What diseases or conditions can be associated with diabetes?

  • High blood pressure.
  • Onset of apple-type obesity – metabolic syndrome.
  • Diabetes or prediabetes (a disorder of carbohydrate metabolism).
  • Laboratory abnormalities: elevated triglycerides (blood fat) levels, elevated LDL “bad cholesterol” levels and reduced HDL “good cholesterol” levels, elevated levels of homocysteine in the blood.

If you already have one of the symptoms of metabolic syndrome, it is likely that other symptoms will also appear over time. People who already have three symptoms of metabolic syndrome are much more likely to have a stroke, heart attack or other heart disease. In metabolic syndrome, blood homocysteine levels are significantly higher, which also leads to a higher incidence of diseases affecting blood vessels. Homocysteine levels are directly related to age, waist circumference, fasting blood glucose, blood fat and uric acid levels.7, 8

How can diabetes be treated?

  • With a diet and lifestyle changes designed by a specialist and a dietician, diabetes patients can achieve spectacular results.
  • However, vitamins, trace minerals and herbs can also be effective in maintaining normal blood glucose levels, and these are most easily consumed in concentrated amounts in the form of supplements.

The GALLMET HEART PLUS capsule contains folate (vitamin B9), betaine, vitamins B6 and B12 in amounts that contribute to proper homocysteine levels in the body, so the chances of complications of diabetes can be significantly reduced!💊

Effect of chromium and terminalia chebula on diabetes

Chromium is a trace element that helps regulate blood glucose levels in glucose intolerance, type 2 diabetes and gestational diabetes and may alleviate diabetic neuropathy. 200 µg/day of supplemental chromium is sufficient for people with mild glucose intolerance, but diabetic women generally need more than 200 µg/day, as do women with gestational diabetes.9, 10

The active ingredients in terminalia chebula extract have significant benefits for blood sugar. 11 Damage to the squamous epithelium (endothelium) lining the inner surface of blood vessels is one of the most important complications of type 2 diabetes and is associated with the risk of cardiovascular disease. The extract of Terminalia chebula can significantly improve endothelial function, reduce oxidative stress and CRP inflammation marker levels in the blood, regulate HbA1c levels and minimise the risk of cardiovascular disease and high blood glucose. 12

[1] The prevalence of diabetic neuropathy and other complications at the University of Debrecen Diabetes Neuropathy Centre - Dr. Ferenc Sztanek, Dr. Bernadett Balogh, Dr. Ágnes Molnár, Dr. Eszter Zöld, Dr. Nóra Tóth, Dr. Áron András Jakab and Dr. György Paragh

[2] Association between plasma homocysteine and progression of early nephropathy in type 2 diabetic patients - Huan Wang, Kai Cui, Ke Xu, and Shixin Xu

[3] Homocysteine - from disease biomarker to disease prevention - Smith AD, Refsum H.

[4] Homocysteine Induces Inflammation in Retina and Brain - Nehal M. Elsherbiny, Isha Sharma, Dina Kira, Suhib Alhusban, Yara A. Samra, Ravirajsinh Jadeja, Pamela Martin, Mohamed Al-Shabrawey and Amany Tawfik

[5] Diabetic eye complications - Diabetic retinopathy and macular oedema

[6] Homocysteine - from disease biomarker to disease prevention - Smith AD, Refsum H.

[7] Elevated Homocysteine Levels Are Associated With the Metabolic Syndrome and Cardiovascular Events in Hypertensive Patients - Cristiana Catena, Gianluca Colussi, Francesca Nait, Frine Capobianco and Leonardo A. Sechi

[8] Metabolic complications of obesity in adolescents, with special reference to the occurrence of elevated uric acid levels - Dr László Ságodi, Dr Viktória Fehér, Dr Emőke Kiss-Tóth, Dr Andrea Almási and Dr László Barkai

[9] Chromium, Glucose Intolerance and Diabetes - Richard A. Anderson PhD

[10] Elevated Intakes of Supplemental Chromium Improve Glucose and Insulin Variables in Individuals With Type 2 Diabetes - Richard A. Anderson, Nanzheng Cheng, Noella A. Bryden, Marilyn M. Polansky, Nanping Cheng, Jiaming Chi and Jinguang Feng

[11] A Review on Potential Mechanisms of Terminalia chebula in Alzheimer's Disease - Amir R. Afshari, Hamid R. Sadeghnia and Hamid Mollazadeh

[12] Effect of an aqueous extract of Terminalia chebula on endothelial dysfunction, systemic inflammation, and lipid profile in type 2 diabetes mellitus: A randomized double-blind, placebo-controlled clinical study - Usharani Pingali, Deepasree Sukumaran, Chandrasekhar Nutalapati

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