Association of gout with kidney damage (nephropathy) and homocysteine levels in the blood

but blood homocysteine levels are significantly higher in gout patients

Alzheimer's disease, Parkinson's disease, mental decline (dementia) and depression

Gout (arthritis uricat) can be hereditary, but it can also be caused by diet, alcohol consumption habits, etc., as well as by improper kidney function, enzyme deficiencies, enzyme dysfunction. Blood uric acid levels are not significantly different between gouty and healthy people, but blood homocysteine levels are significantly higher in gout patients. Impaired renal function is associated with blood homocysteine levels and with the likelihood of developing and worsening gout.1 Renal failure is the most common cause of death in gout patients. High level of homocysteine cause kidney damage and thus play a role in the development of chronic renal failure.2 Laboratory eGFR is a measure of kidney function, with lower levels associated with higher homocysteine levels and a one unit increase in homocysteine is associated with more than 8 times the risk of elevated blood uric acid levels, which contributes to the development of gout.3

But what is homocysteine?

Homocysteine is an amino acid that is essential for normal cell function, but high homocysteine levels have undesirable effects. These include the symptoms listed below, but in addition to these, over 100 diseases or conditions, mainly cardiovascular, have been identified that are associated with elevated blood plasma homocysteine levels.4 Read more about homocysteine HERE.

What can I do about gout?

  • Avoiding alcohol,
  • gout diet,
  • drinking plenty of fluids (2-3 litres/day):
    • non-carbonated water,
    • medicinal waters (e.g. Balfi, Parádi, Salvus),
    • nettle tea.
  • Vitamin C and D supplementation,
  • calcium supplementation,
  • reducing homocysteine levels.

GALLMET Heart Plus capsules contain folate (vitamin B9), betaine, vitamins B6 and B12, which contribute to the body's proper homocysteine levels!💊

What ingredients are effective against gout?

People with high homocysteine levels have higher blood levels of uric acid and lower levels of folate (vitamin B9) and vitamin B12 than healthy people. Vitamin B9 (folate) and vitamin B12 may be useful for high uric acid and homocysteine levels in vascular disorders such as kidney damage.5
Folate reduces uric acid levels to a greater extent the higher the homocysteine level. 6 The folate intake of people in central Europe is also very low at only about a third of the level recommended in dietary recommendations.7 In addition to this, many of the foods that are forbidden or avoided in the gout diet are also the main source of vitamin B12, so vitamin B12 deficiency can be exacerbated.

It should be noted that many products containing vitamin B9 contain folic acid, while the bioavailability of folic acid is not the same as natural folate in patients with common gene defects – MTHFR 1298C and C677T. Folic acid does not directly reduce homocysteine levels but can cause kidney damage and, unlike natural folate, does not cross the blood-brain barrier!8

How do I know for sure if my homocysteine level is high?

A betaine-rich diet may be effective in reducing the risk of cardiovascular disease.9 Supplementation with betaine is most important in patients who do not respond to vitamin B6 supplementation and in those who do not follow a low protein and low methionine diet.10

[1] Elevated Serum Homocysteine Levels Were Not Correlated with Serum Uric Acid Levels, but with Decreased Renal Function in Gouty Patients - Sang Tae Choi, Jin Su Kim and Jung-Soo Song

[2] Homocysteine in Renal Injury - Yanjun Longa and Jing Niea

[3] Serum Homocysteine Level Is Positively Correlated With Serum Uric Acid Level in U.S. Adolescents: A Cross Sectional Study - Yumeng Shi, Zuxiang Wu, Ji Wu, Zhiqiang Chen and Ping Li

[4] Homocysteine - from disease biomarker to disease prevention - Smith AD, Refsum H.

[5] The Different Relationship between Homocysteine and Uric Acid Levels with Respect to the MTHFR C677T Polymorphism According to Gender in Patients with Cognitive Impairment - Hee-Jin Kim, Il Woong Sohn, Young Seo Kim and Jae-Bum Jun

[6] Folic acid therapy reduces serum uric acid in hypertensive patients: a substudy of the China Stroke Primary Prevention Trial (CSPPT) - Xianhui Qin, Youbao Li, Mingli He, Genfu Tang, Delu Yin, Min Liang, Binyan Wang, Jing Nie, Yong Huo, Xin Xu and Fan Fan Hou

[7] The role of homocysteine in the pathogenesis of early-onset ischaemic heart disease - Dr. Lajos Szollár

[8] New Evidence for Homocysteine Lowering for Management of Treatment-Resistant Hypertension - Merrill F. Elias and Craig J. Brown

[9] Human Nutrition and Metabolism Research Communication - Margreet R. Olthof, Trinette van Vliet, Esther Boelsma and Petra Verhoef

[10] Health Functionalities of Betaine in Patients With Homocystinuria - Truitt C, Hoff WD, Deole R.

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